Drug Information
Drug General Information | |||||
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Drug ID |
D05FWH
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Former ID |
DNCL002660
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Drug Name |
SCH-900776
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Drug Type |
Small molecular drug
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Company |
Merck
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Structure |
Download2D MOL |
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Formula |
C15H18BrN7
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InChI |
InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3
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InChIKey |
GMIZZEXBPRLVIV-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [531364] | |
Pathway Interaction Database | Fanconi anemia pathway | ||||
p73 transcription factor network | |||||
ATR signaling pathway | |||||
Circadian rhythm pathway | |||||
p53 pathway | |||||
Reactome | Activation of ATR in response to replication stress | ||||
Processing of DNA double-strand break ends | |||||
Presynaptic phase of homologous DNA pairing and strand exchange | |||||
G2/M DNA damage checkpoint | |||||
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
References | |||||
Ref 524312 | ClinicalTrials.gov (NCT01870596) Cytarabine With or Without SCH 900776 in Treating Adult Patients With Relapsed Acute Myeloid Leukemia. U.S. National Institutes of Health. | ||||
Ref 542858 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7943). |
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