Drug General Information
Drug ID	D05FQD
Former ID	DNCL002685
Drug Name	Metaiodobenzylguanidine I-131
Synonyms	Azedra (TN)
Drug Type	Small molecular drug
Indication	Neuroblastoma [ICD9: 194.0, 194.5, 194.6, 227.0, 227.5, 227.6, 237.3, 255.6; ICD10:C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7]		Phase 2	[1]
Company	Molecular Insights Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C8H10IN3
Canonical SMILES	C1=CC(=CC(=C1)I)CN=C(N)N
InChI	1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)/i9+4
InChIKey	PDWUPXJEEYOOTR-JRGAVVOBSA-N
PubChem Compound ID	71184
PubChem Substance ID	944, 12013292, 15222169, 17397459, 24438381, 43127562, 50065200, 57318057, 77939173, 104349861, 117526270, 128901923, 135027866, 136939998, 137240339, 139866414, 175266151, 238095867, 241137445
Target and Pathway
Target(s)	Sodium-dependent noradrenaline transporter	Target Info	Modulator	[2]
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
Reactome	Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
REF 1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004852)
REF 2	Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res. 2014 Apr 15;20(8):2182-91.

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