Drug Information

Drug General Information
Drug ID
D05ETM
Former ID
DNC000478
Drug Name
CP-99,994
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539331]
Structure
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2D MOL

3D MOL
Formula
C19H24N2O
InChI
InChI=1S/C19H24N2O/c1-22-18-12-6-5-10-16(18)14-21-17-11-7-13-20-19(17)15-8-3-2-4-9-15/h2-6,8-10,12,17,19-21H,7,11,13-14H2,1H3/t17-,19-/m0/s1
InChIKey
DTQNEFOKTXXQKV-HKUYNNGSSA-N
CAS Number
CAS 20830-81-3
PubChem Compound ID
5311057
PubChem Substance ID
7978996, 11056241, 14775946, 14898203, 39340786, 57359339, 74507627, 103191689, 103914740, 114155166, 127785450, 134341384, 135650132, 137119919, 140143305, 224962361, 227508080
ChEBI ID
ChEBI:41977
SuperDrug ATC ID
L01DB02
SuperDrug CAS ID
cas=020830813
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [535587]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539331(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2102).
Ref 535587Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain. J Pharmacol Exp Ther. 2002 Nov;303(2):730-5.

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