Drug General Information
Drug ID	D05DTJ
Former ID	DNC012295
Drug Name	3-Phenyl-1-propyl-piperidine hydrochloride
Indication	Discovery agent		Investigative	[526495]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1=CC(=CN=C1)C(=O)CCl.Cl
InChI	1S/C7H6ClNO.ClH/c8-4-7(10)6-2-1-3-9-5-6;/h1-3,5H,4H2;1H
InChIKey	PBIUDEUWYGBHDW-UHFFFAOYSA-N
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Inhibitor	[526495]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 526495	J Med Chem. 2003 Jan 2;46(1):161-8.New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.
Ref 526495	J Med Chem. 2003 Jan 2;46(1):161-8.New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.