Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05DON
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| Former ID |
DIB004320
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| Drug Name |
MILACAINIDE TARTRATE
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| Synonyms |
(R)-RO-22-9194.tartrate; 2(R)-Amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate
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| Indication | Cardiac arrhythmias [ICD9: 427; ICD10:I47-I49] | Discontinued in Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
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| Target and Pathway | |||||
| Target(s) | Thromboxane-A synthase | Target Info | Antagonist | [2] | |
| BioCyc Pathway | C20 prostanoid biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Platelet activation | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Arachidonic acid metabolism | |||||
| Phase 1 - Functionalization of compounds | |||||
| Eicosanoid Synthesis | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001597) | ||||
| REF 2 | Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity. J Pharmacol Exp Ther. 1996 Nov;279(2):877-83. | ||||
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