Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05CFH
|
||||
| Former ID |
DCL000684
|
||||
| Drug Name |
AGN-199981
|
||||
| Indication | Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] | Phase 2 | [1] | ||
| Therapeutic Class |
Analgesics
|
||||
| Company |
Allergan
|
||||
| Target and Pathway | |||||
| Target(s) | Alpha-2B adrenergic receptor | Target Info | Agonist | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. | ||||
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