Drug Information

Drug General Information
Drug ID
D05BMG
Former ID
DIB014351
Drug Name
Amphetamine
Synonyms
Amphetamine (tamper and abuse-resistant, Bio-MD/MPAR, ADHD); Amphetamine (tamper and abuse-resistant, Bio-MD/MPAR, ADHD), PharmacoFore; PF-08 (Bio-MD/MPAR/prodrug/oral, ADHD), PharmacoFore
Drug Type
Small molecular drug
Indication Attention deficit disorder with hyperactivity [ICD10:F90] Approved [551871]
Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] Investigative [468035], [526471], [526676], [532175], [532852], [551871]
Company
PharmacoFore Inc
Structure
Download
2D MOL
Formula
C9H13N
InChI
InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3
InChIKey
KWTSXDURSIMDCE-UHFFFAOYSA-N
PubChem Compound ID
3007
PubChem Substance ID
9717, 87765, 115861, 608004, 3249024, 5340423, 7978700, 8150111, 8151914, 10517686, 10524938, 10529136, 11336166, 11361405, 11462377, 11533323, 15297279, 24882028, 26746621, 31073245, 35804947, 36519861, 36651428, 39909068, 46506414, 47216854, 48110531, 48415560, 49855301, 49855567, 51091776, 53789505, 57321551, 57651795, 77830611, 85209571, 85756449, 99302079, 103164180, 103810791, 103918755, 104302255, 117525983, 125680154, 126677500, 127272449, 127272450, 127272451, 127272452, 127272453
Target and Pathway
Target(s) Trace amine-associated receptor-1 Target Info Modulator [526471], [526676], [532175], [532852], [551871]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome G alpha (s) signalling events
References
Ref 468035(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4804).
Ref 526471Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8.
Ref 526676Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003 Jul;86(2):413-21.
Ref 532175Involvement of the alpha(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res. 2013 Aug;24(2):130-8.
Ref 532852Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 526471Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8.
Ref 526676Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003 Jul;86(2):413-21.
Ref 532175Involvement of the alpha(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res. 2013 Aug;24(2):130-8.
Ref 532852Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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