Drug General Information
Drug ID
D05BGM
Former ID
DNC014099
Drug Name
Eusynstyelamide C
Indication Discovery agent Investigative [530193]
Structure
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2D MOL

3D MOL

Canonical SMILES
C1=CC2=C(C=C1Br)NC=C2CC3(C(C(N(C3=O)CCCCN=C(N)N)(C(=O)N<br />CCCCN=C(N)N)O)C4=CNC5=C4C=CC(=C5)Br)O
InChI
1S/C32H40Br2N10O4/c33-19-5-7-21-18(16-42-24(21)13-19)15-31(47)26(23-17-43-25-14-20(34)6-8-22(23)25)32(48,27(45)39-9-1-2-10-40-29(35)36)44(28(31)46)12-4-3-11-41-30(37)38/h5-8,13-14,16-17,26,42-43,47-48H,1-4,9-12,15H2,(H,39,45)(H4,35,36,40)(H4,37,38,41)/t26-,31-,32+/m1/s1
InChIKey
AFCHPUCHYPXZGZ-WBKIGWJKSA-N
Target and Pathway
Target(s) Nitric-oxide synthase, brain Target Info Inhibitor [530193]
BioCyc Pathway Citrulline-nitric oxide cycle
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
Phagosome
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
NetPath Pathway EGFR1 Signaling Pathway
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Arginine and Proline Metabolism
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter Activity
References
Ref 530193J Nat Prod. 2009 Jun;72(6):1115-20.Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius.
Ref 530193J Nat Prod. 2009 Jun;72(6):1115-20.Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius.

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