Drug Information

Drug General Information
Drug ID
D05ARP
Former ID
DAP000645
Drug Name
Ganciclovir
Synonyms
Citovirax; Cymevan; Cymeven; Cymevene; Cytovene; Ganciclovirum; Gancyclovir; HHEMG; Hydroxyacyclovir; Virgan; Vitrasert; Zirgan; GANCICLOVIR SODIUM; Ganciclovirum [Latin]; BW 759; BW 759U; Biolf 62; G 2536; GA2; IN1478; MB3795; BIOLF-62; BW-759U; BW-795; BW-B 759U; Cymevene (TN); Cytovene (TN); Cytovene-IV; DRG-0018; GCV & 1110U81; GCV & MSL; RS-21592; ST-605; Vitrasert (TN); Ganciclovir & C34-dgA immunotoxin; Ganciclovir & D5-dgA immunotoxin; Ganciclovir (JAN/USP/INN); Ganciclovir [USAN:INN:BAN:JAN]; Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-and MSL, neutralizing monoclonal antibody; 2'-NDG; 2'-Nor-2'-deoxyguanosine; 2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol; 2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one; 2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one; 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one; 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one; 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol; 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one; 2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone; 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one; 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one; 9-((1,3-Dihydroxy-2-propoxy)methyl)guanine; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine; 9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; GCV
Drug Type
Small molecular drug
Indication Viral infections [ICD9: 054.0, 054.1, 054.2, 054.3, 075, 771.2, 052, 053; ICD10:B01, B02, A60, B00, B27, G05.1, P35.2] Approved [536361]
Therapeutic Class
Antiviral Agents
Company
Bausch & Lomb Pharmaceuticals, Inc.
Structure
Download
2D MOL

3D MOL
Formula
C9H13N5O4
Canonical SMILES
C1=NC2=C(N1COC(CO)CO)NC(=NC2=O)N
InChI
1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChIKey
IRSCQMHQWWYFCW-UHFFFAOYSA-N
CAS Number
CAS 82410-32-0
PubChem Compound ID
3454
PubChem Substance ID
617697, 866342, 3720872, 5006228, 7298558, 7840003, 7847399, 7887702, 7979369, 8139883, 10321977, 11111224, 11111225, 11466867, 11467987, 11486454, 12013652, 14749970, 14798783, 16217245, 17405102, 23929519, 24278453, 25622077, 26758755, 29222588, 46507294, 47216865, 47515408, 47589082, 48185084, 48185085, 48334596, 48404464, 48404465, 49681203, 49698657, 49974979, 50106328, 50106329, 50113251, 53777645, 53800918, 56312143, 56312588, 56424026, 57321811, 76491727, 81041223, 85231063
SuperDrug ATC ID
J05AB06; S01AD09
SuperDrug CAS ID
cas=082410320
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) DNA polymerase Target Info Inhibitor [537548]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 537548Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81.

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