Drug General Information
Drug ID	D05ARI
Former ID	DNC011847
Drug Name	Propyl-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533152]
Structure		Download 2D MOL 3D MOL
Formula	C10H17N3
Canonical SMILES	CCCNC1CCC2=C(C1)C=NN2
InChI	1S/C10H17N3/c1-2-5-11-9-3-4-10-8(6-9)7-12-13-10/h7,9,11H,2-6H2,1H3,(H,12,13)
InChIKey	PYXYUOJSCYNCKM-UHFFFAOYSA-N
PubChem Compound ID	14539719
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Inhibitor	[533152]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 533152	J Med Chem. 1989 Oct;32(10):2388-96.Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity.
Ref 533152	J Med Chem. 1989 Oct;32(10):2388-96.Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity.

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