Drug General Information
Drug ID	D05ACQ
Former ID	DIB012725
Drug Name	Gallium maltolate
Synonyms	GaM
Drug Type	Small molecular drug
Indication	Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26]		Discontinued in Phase 2	[547230]
Company	Titan Pharmaceuticals; Geomed Inc
Structure		Download 2D MOL 3D MOL
Formula	C18H15GaO9
Canonical SMILES	c1(c(=O)ccoc1C)[O-].[GaH3+3].c1(c(=O)ccoc1C)[O-].c1(c(=<br />O)ccoc1C)[O-]
CAS Number	CAS 108560-70-9
PubChem Compound ID	9846339
Target and Pathway
Target(s)	Ribonucleoside-diphosphatereductase subunit M2	Target Info	Binder	[528297]
BioCyc Pathway	Pyrimidine deoxyribonucleotides biosynthesis from CTP
	Pyrimidine deoxyribonucleotides de novo biosynthesis
	Guanosine nucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of purine nucleotide salvage
	Purine nucleotides de novo biosynthesis
	Adenosine deoxyribonucleotides de novo biosynthesis
	Guanosine deoxyribonucleotides de novo biosynthesis
KEGG Pathway	Purine metabolism
	Pyrimidine metabolism
	Glutathione metabolism
	Metabolic pathways
	p53 signaling pathway
NetPath Pathway	EGFR1 Signaling Pathway
PANTHER Pathway	p53 pathway
	De novo purine biosynthesis
	De novo pyrimidine deoxyribonucleotide biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Purine Metabolism
	Pyrimidine Metabolism
Reactome	E2F mediated regulation of DNA replication
	G1/S-Specific Transcription
WikiPathways	Nucleotide Metabolism
	Retinoblastoma (RB) in Cancer
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 547230	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014315)
Ref 528297	Gallium maltolate is a promising chemotherapeutic agent for the treatment of hepatocellular carcinoma. Anticancer Res. 2006 May-Jun;26(3A):1739-43.

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