Drug General Information
Drug ID	D04ZND
Former ID	DIB009471
Drug Name	PGL-2001
Synonyms	Steroid sulfatase inhibitor (endometriosis), PregLem
Indication	Endometriosis [ICD9: 617; ICD10:N80]		Phase 2	[523963]
Company	Ipsen
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Steryl-sulfatase	Target Info	Inhibitor	[532697]
KEGG Pathway	Steroid hormone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	Glycosphingolipid metabolism
WikiPathways	Estrogen metabolism
	Vitamin D Receptor Pathway
	Sphingolipid metabolism
References
Ref 523963	ClinicalTrials.gov (NCT01631981) PGL2001 Proof of Concept Study in Symptomatic Endometriosis. U.S. National Institutes of Health.
Ref 532697	Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21(10):1256-65.

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