Drug General Information
Drug ID
D04ZJG
Former ID
DCL000197
Drug Name
PI-88
Drug Type
Small molecular drug
Indication Hepatocellular carcinoma [ICD9: 155; ICD10:C22.0] Phase 3 [537114]
Prostate cancer; Lung cancer [ICD9: 140-229, 162, 185; ICD10:C33-C34, C61] Phase 2 [537114]
Therapeutic Class
Anticancer Agents
Company
Progen Industries
Structure
Download
2D MOL

3D MOL

Formula
C30H35Na15O77PS16-3
Canonical SMILES
C(C1C(C(C(C(O1)OC2C(C(OC(C2OS(=O)(=O)[O-])OC3C(C(OC(C3O<br />S(=O)(=O)[O-])OC4C(C(OC(C4OS(=O)(=O)[O-])OC5C(C(C(OC5OS<br />(=O)(=O)[O-])COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[<br />O-])COS(=O)(=O)[O-])OS(=O)(=O)[O-])COS(=O)(=O)[O-])OS(=<br />O)(=O)[O-])COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-<br />])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OP(=O)([O-])[O-].[Na+].<br />[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[<br />Na+].[Na+].[Na+].[Na+].[Na+]
InChI
1S/C30H53O77PS16.15Na/c31-108(32,33)82-1-6-14(99-116(55,56)57)20(102-119(64,65)66)25(106-123(76,77)78)29(87-6)94-17-12(97-114(49,50)51)8(3-84-110(37,38)39)89-27(23(17)104-121(70,71)72)92-16-11(96-113(46,47)48)7(2-83-109(34,35)36)88-26(22(16)103-120(67,68)69)93-18-13(98-115(52,53)54)9(4-85-111(40,41)42)90-28(24(18)105-122(73,74)75)95-21-19(101-118(61,62)63)15(100-117(58,59)60)10(5-86-112(43,44)45)91-30(21)107-124(79,80)81;;;;;;;;;;;;;;;/h6-30H,1-5H2,(H2,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)(H,73,74,75)(H,76,77,78)(H,79,80,81);;;;;;;;;;;;;;;/q;15*+1/p-18/t6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17+,18+,19+,20+,21+,22+,23+,24+,25+,26-,27-,28-,29-,30-;;;;;;;;;;;;;;;/m1.............../s1
InChIKey
FIYNUMVQYZZZCH-JSZMYKOGSA-A
CAS Number
CAS 223576-45-2
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 3 Target Info Modulator
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesion
NetPath Pathway TNFalpha Signaling Pathway
Pathway Interaction Database VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endothelium
Reactome VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Signaling by VEGF
References
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.

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