Drug Information
Drug General Information | |||||
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Drug ID |
D04WWO
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Former ID |
DNC014796
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Drug Name |
IM-491
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529165] | ||
Structure |
Download2D MOL |
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Formula |
C25H28N4O4
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Canonical SMILES |
CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)NC(=O)C4C(CCCN4C)C<br />(=O)NO
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InChI |
1S/C25H28N4O4/c1-16-14-17(20-6-3-4-8-22(20)26-16)15-33-19-11-9-18(10-12-19)27-25(31)23-21(24(30)28-32)7-5-13-29(23)2/h3-4,6,8-12,14,21,23,32H,5,7,13,15H2,1-2H3,(H,27,31)(H,28,30)/t21-,23-/m0/s1
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InChIKey |
RJSKOAOWDAMMHR-GMAHTHKFSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | ADAM 17 | Target Info | Inhibitor | [529165] | |
Pathway Interaction Database | ErbB4 signaling events | ||||
TNF receptor signaling pathway | |||||
p75(NTR)-mediated signaling | |||||
Reactome | Nuclear signaling by ERBB4 | ||||
Collagen degradation | |||||
Regulated proteolysis of p75NTR | |||||
Activated NOTCH1 Transmits Signal to the Nucleus | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 t(7 | |||||
M1580_K2555) Translocation Mutant | |||||
Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
TNF signaling | |||||
Growth hormone receptor signaling | |||||
References |
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