Drug General Information
Drug ID
D04WPG
Former ID
DAP000831
Drug Name
Valproic Acid
Synonyms
Avugane; Baceca; Convulex; Convulsofin; Depakene; Depakin; Depakine; Deproic; Dipropylacetate; Ergenyl; Mylproin; Savicol; Stavzor; VPA; Valproate; Valproinsaeure; Vupral; Acide valproique; Acido valproico; Acidum valproicum; Depakin chrono; Depakine chrono; Dipropyl Acetate; Dipropylacetic acid; Med Valproic; Myproic Acid; Propylvaleric acid; Semisodium Valproate; Valproic acid USP; Abbott 44090; Valproic acid USP24; Acide valproique [INN-French]; Acido valproico [INN-Spanish]; Acidum valproicum [INN-Latin]; Alti-Valproic; Convulex (TN); Depacon (TN); Depakene (TN); Depakote (TM); Depakote (TN); Depakote ER (TN); Dom-Valproic; Encorate (TN); Epilim (TN); Epival (TN); G2M-777; Kyselina 2-propylvalerova; Kyselina 2-propylvalerova [Czech]; N-DPA; N-Dipropylacetic acid; Novo-Valproic; Nu-Valproic; PMS-Valproic Acid; Penta-Valproic; Stavzor (TN); Valproic acid (USP); Winthrop (TN); Di-n-propylacetic acid; Di-n-propylessigsaeure; Di-n-propylessigsaure; Di-n-propylessigsaure [German]; Valproic acid [USAN:INN:BAN]; Valproic Acid, Sodium Salt (2:1); 2 PP (base); 2-Propylpentanoic acid; 2-Propylvaleric acid; 2-n-Propyl-n-valeric acid; 4-Heptanecarboxylic acid
Drug Type
Small molecular drug
Indication Epilepsy [ICD10:G40] Approved [536447], [542039], [551871]
Therapeutic Class
Anticonvulsants
Company
Abbott Laboratories; TopoTarget
Structure
Download
2D MOL

3D MOL

Formula
C8H16O2
InChI
InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
InChIKey
NIJJYAXOARWZEE-UHFFFAOYSA-N
CAS Number
CAS 99-66-1
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:39867
SuperDrug ATC ID
N03AG01
SuperDrug CAS ID
cas=000099661
Target and Pathway
Target(s) Histone deacetylase Target Info Inhibitor [535221], [536272], [537490], [537523], [537552]
References
Ref 536447Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
Ref 542039(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7009).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535221The new generation of GABA enhancers. Potential in the treatment of epilepsy. CNS Drugs. 2001;15(5):339-50.
Ref 536272Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84.
Ref 537490Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. Mol Biochem Parasitol. 2009 Jun 16.
Ref 537523Histone Deacetylase 2 is a Key Regulator of Diabetes and Transforming Growth Factor-{beta}1-Induced Renal Injury. Am J Physiol Renal Physiol. 2009 Jun 24.
Ref 537552Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. PLoS One. 2009 Jun 30;4(6):e6086.

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