Drug Information
Drug General Information | |||||
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Drug ID |
D04WFL
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Former ID |
DAP000391
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Drug Name |
Trastuzumab
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Synonyms |
Herceptin; Herceptin (TN); Trastuzumab (INN); Trastuzumab (genetical recombination); Trastuzumab (genetical recombination) (JAN); Trastuzumab (ERBB2 mAb inhibitor)
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Drug Type |
Antibody
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Therapeutic Class |
Anticancer Agents
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Company |
Roche; Genentech
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Formula |
C6470H10012N1726O2013S42
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CAS Number |
CAS 180288-69-1
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PubChem Substance ID | |||||
SuperDrug ATC ID |
L01XC03
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SuperDrug CAS ID |
cas=180288691
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Drug Resistance Mutation (DRM) | |||||
DRM | DRM Info | ||||
Target and Pathway | |||||
Target(s) | Receptor protein-tyrosine kinase erbB-2 | Target Info | [535355], [535660], [535976] | ||
KEGG Pathway | ErbB signaling pathway | ||||
Calcium signaling pathway | |||||
HIF-1 signaling pathway | |||||
Focal adhesion | |||||
Adherens junction | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
MicroRNAs in cancer | |||||
Pancreatic cancer | |||||
Endometrial cancer | |||||
Prostate cancer | |||||
Bladder cancer | |||||
Non-small cell lung cancer | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Cadherin signaling pathway | ||||
EGF receptor signaling pathway | |||||
PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
WikiPathways | DNA Damage Response (only ATM dependent) | ||||
ErbB Signaling Pathway | |||||
EGF/EGFR Signaling Pathway | |||||
Focal Adhesion | |||||
Extracellular vesicle-mediated signaling in recipient cells | |||||
Bladder Cancer | |||||
Signaling by ERBB2 | |||||
Integrated Pancreatic Cancer Pathway | |||||
Signaling Pathways in Glioblastoma | |||||
Leptin signaling pathway | |||||
miR-targeted genes in muscle cell - TarBase | |||||
Semaphorin interactions | |||||
References | |||||
Ref 468150 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5082). | ||||
Ref 532651 | 2013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9. | ||||
Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
Ref 535355 | Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines. Cancer Immunol Immunother. 2002 Jan;50(11):569-87. Epub 2001 Nov 24. | ||||
Ref 535660 | Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51. | ||||
Ref 535976 | Her2/neu is not a commonly expressed therapeutic target in melanoma -- a large cohort tissue microarray study. Melanoma Res. 2004 Jun;14(3):207-10. |
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