| Drug General Information |
| Drug ID |
D04TVG
|
| Former ID |
DIB019020
|
| Drug Name |
BRL-15572
|
| Synonyms |
BRL15572; BRL-15,572; BRL 15572
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C25H27ClN2O
|
| InChI |
InChI=1S/C25H27ClN2O/c26-22-12-7-13-23(18-22)28-16-14-27(15-17-28)19-24(29)25(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,18,24-25,29H,14-17,19H2
|
| InChIKey |
QJHCTHPYUOXOGM-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
4985039, 7978816, 9828483, 26752103, 37849166, 47275542, 47349353, 47646554, 48018896, 48243354, 50104759, 53180552, 57356460, 81065496, 85208982, 85788307, 90340857, 112038967, 123090458, 124749523, 124879458, 124879459, 124879460, 135305566, 135610871, 135650023, 136351265, 162220570, 233322324, 249817508, 249820161
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1F receptor |
Target Info |
Agonist |
[2]
|
|---|
| 5-hydroxytryptamine 1E receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 1B receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 6 receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 1D receptor |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04024:cAMP signaling pathway
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
|
|
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathway
|
|
PathWhiz Pathway
|
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Serotonin HTR1 Group and FOS Pathway
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
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GPCR downstream signaling
|
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GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
|
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GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
|
|
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
SIDS Susceptibility Pathways
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 10). |
|---|
| REF 2 | SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. |
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