Drug General Information
Drug ID
D04SQY
Former ID
DIB019715
Drug Name
deoxycorticosterone
Synonyms
11-deoxycorticosterone; 21-hydroxyprogesterone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539897]
Structure
Download
2D MOL
Formula
C21H30O3
InChI
InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1
InChIKey
ZESRJSPZRDMNHY-YFWFAHHUSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) mRNA of glucocorticoid receptor Target Info Agonist [525736]
Mineralocorticoid receptor Target Info Agonist [533966]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04960:Aldosterone-regulated sodium reabsorption
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
PathWhiz Pathway Kidney Function
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear ReceptorsWP554:ACE Inhibitor Pathway
References
Ref 539897(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2871).
Ref 525736Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding. J Biol Chem. 2000Jun 23;275(25):19041-9.
Ref 533966Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol. 1993 Oct 15;247(2):145-54.

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