Drug Information
Drug General Information | |||||
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Drug ID |
D04SLF
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Former ID |
DCL000497
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Drug Name |
Bevacizumab + Trastuzumab
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Drug Type |
Antibody
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Company |
Roche
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Structure |
Download2D MOL |
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Formula |
C24H40O3
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Vascular endothelial growth factor | Target Info | Inhibitor | [551607] | |
Receptor protein-tyrosine kinase erbB-2 | Target Info | [551607] | |||
KEGG Pathway | ErbB signaling pathway | ||||
Calcium signaling pathway | |||||
HIF-1 signaling pathway | |||||
Focal adhesion | |||||
Adherens junction | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
MicroRNAs in cancer | |||||
Pancreatic cancer | |||||
Endometrial cancer | |||||
Prostate cancer | |||||
Bladder cancer | |||||
Non-small cell lung cancer | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Cadherin signaling pathway | ||||
EGF receptor signaling pathway | |||||
PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
WikiPathways | DNA Damage Response (only ATM dependent) | ||||
ErbB Signaling Pathway | |||||
EGF/EGFR Signaling Pathway | |||||
Focal Adhesion | |||||
Extracellular vesicle-mediated signaling in recipient cells | |||||
Bladder Cancer | |||||
Signaling by ERBB2 | |||||
Integrated Pancreatic Cancer Pathway | |||||
Signaling Pathways in Glioblastoma | |||||
Leptin signaling pathway | |||||
miR-targeted genes in muscle cell - TarBase | |||||
Semaphorin interactions | |||||
References | |||||
Ref 532301 | AVEREL: a randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer. J Clin Oncol. 2013 May 10;31(14):1719-25. | ||||
Ref 554002 | ClinicalTrials.gov (NCT00365365) Safety & Efficacy of Three Docetaxel-Based Chemotherapy Regimens Plus Bevacizumab With or Without Trastuzumab for Adjuvant Treatment of Patients With Breast Cancer |
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