Drug General Information
Drug ID	D04SCD
Former ID	DNC004771
Drug Name	6-Chloro-4-morpholin-4-yl-chromen-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527386]
Structure		Download 2D MOL 3D MOL
Formula	C13H12ClNO3
Canonical SMILES	C1COCCN1C2=CC(=O)OC3=C2C=C(C=C3)Cl
InChI	1S/C13H12ClNO3/c14-9-1-2-12-10(7-9)11(8-13(16)18-12)15-3-5-17-6-4-15/h1-2,7-8H,3-6H2
InChIKey	IKOYKMNERRYCAN-UHFFFAOYSA-N
PubChem Compound ID	11459783
Target and Pathway
Target(s)	DNA-dependent protein kinase catalytic subunit	Target Info	Inhibitor	[527386]
KEGG Pathway	Non-homologous end-joining
	Cell cycle
NetPath Pathway	IL1 Signaling Pathway
Pathway Interaction Database	DNA-PK pathway in nonhomologous end joining
	Coregulation of Androgen receptor activity
	Class I PI3K signaling events mediated by Akt
	BARD1 signaling events
Reactome	Nonhomologous End-Joining (NHEJ)
WikiPathways	DNA Damage Response
	Non-homologous end joining
	FAS pathway and Stress induction of HSP regulation
	Cytosolic sensors of pathogen-associated DNA
	Retinoblastoma (RB) in Cancer
	Prostate Cancer
	Double-Strand Break Repair
	Cell Cycle
	miRNA Regulation of DNA Damage Response
References
Ref 527386	J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386	J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

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