TTD | Drug: D04QUX

Drug General Information
Drug ID	D04QUX
Former ID	DIB011713
Drug Name	PF-446687
Synonyms	PF-00446687; PF-2336652
Indication	Female sexual dysfunction [ICD9: 302.7; ICD10:F52]		Phase 2	[522609]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[C@@H]1([C@@H](CN(C1)C(C)(C)C)c1ccc(cc1F)F)C(=O)N1C[C@H<br />]([C@](c2ccccc2)([C@H](C1)C)O)C.Cl
Target and Pathway
Target(s)	Melanocortin-4 receptor	Target Info	Modulator	[533131]
KEGG Pathway	Neuroactive ligand-receptor interaction
Pathway Interaction Database	Syndecan-3-mediated signaling events
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (s) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522609	ClinicalTrials.gov (NCT00862888) Study to Investigate Effect of a New Drug (PF-00446687) in Males Suffering From Erectile Dysfunction. U.S. National Institutes of Health.
Ref 533131	Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.

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Drug Information