Drug General Information
Drug ID	D04QGH
Drug Name	Piragliatin
Synonyms	GK2; R1440; RO4389620
Drug Type	Small molecular drug
Indication	Unspecified		Investigative	[1559882]
Therapeutic Class	Endocrine, nutritional and metabolic diseases
Structure		Download 2D MOL 3D MOL
Formula	C19H20ClN3O4S
PubChem Compound ID	10432339
Target and Pathway
Target(s)	Glucokinase	Target Info	Modulator
KEGG Pathway	Glycolysis / Gluconeogenesis
	Galactose metabolism
	Starch and sucrose metabolism
	Amino sugar and nucleotide sugar metabolism
	Butirosin and neomycin biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
	Carbon metabolism
	Insulin signaling pathway
	Insulin secretion
	Prolactin signaling pathway
	Glucagon signaling pathway
	Type II diabetes mellitus
	Maturity onset diabetes of the young
	Central carbon metabolism in cancer
Pathway Interaction Database	FOXA2 and FOXA3 transcription factor networks
	HIF-1-alpha transcription factor network
PathWhiz Pathway	Nucleotide Sugars Metabolism
	Starch and Sucrose Metabolism
	Galactose Metabolism
	Trehalose Degradation
Reactome	Regulation of gene expression in beta cells
	Glucose transport
	Glycolysis
WikiPathways	SIDS Susceptibility Pathways
	Glycolysis and Gluconeogenesis
	MAPK Signaling Pathway
	Regulation of beta-cell development
	Metabolism of carbohydrates
	Hexose transport
References
Ref 1559882	Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study.J Clin Endocrinol Metab.2010 Nov;95(11):5028-36.

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