Drug General Information
Drug ID
D04QDB
Former ID
DNC006919
Drug Name
ABT-341
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528488]
Structure
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2D MOL

3D MOL

Formula
C21H18F9N5O3
Canonical SMILES
C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C3=CCC(C(C3)N)C4=CC(=C(C(<br />=C4)F)F)F.C(=O)(C(F)(F)F)O
InChI
1S/C19H17F6N5O.C2HF3O2/c20-12-5-10(6-13(21)16(12)22)11-2-1-9(7-14(11)26)17(31)29-3-4-30-15(8-29)27-28-18(30)19(23,24)25;3-2(4,5)1(6)7/h1,5-6,11,14H,2-4,7-8,26H2;(H,6,7)/t11-,14+;/m1./s1
InChIKey
JKIHWNQARLENJW-GGMFNZDASA-N
PubChem Compound ID
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Inhibitor [528488]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 528488J Med Chem. 2006 Nov 2;49(22):6439-42.Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Ref 528488J Med Chem. 2006 Nov 2;49(22):6439-42.Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

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