Drug General Information
Drug ID
D04PVN
Former ID
DCL000997
Drug Name
SPI-376
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Preclinical [536463]
Company
Spectrum Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C20H24ClN3O
Canonical SMILES
C1CC2=C(C=CN2CCN3CCN(CC3)C4=CC(=CC=C4)Cl)C(=O)C1
InChI
1S/C20H24ClN3O/c21-16-3-1-4-17(15-16)23-12-9-22(10-13-23)11-14-24-8-7-18-19(24)5-2-6-20(18)25/h1,3-4,7-8,15H,2,5-6,9-14H2
InChIKey
CQSQHUPRBBCQRE-UHFFFAOYSA-N
CAS Number
CAS 496921-73-4
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
N06AX14
SuperDrug CAS ID
cas=066981735
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Binder [536463]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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