Drug General Information
Drug ID	D04PAU
Former ID	DNCL003606
Drug Name	GSK2245035
Synonyms	GSK-2245035
Indication	Asthma [ICD10:J45]		Phase 2	[523920]
Company	GlaxoSmithKline
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Toll-like receptor 7	Target Info	Modulator	[533262]
KEGG Pathway	Toll-like receptor signaling pathway
	Measles
	Influenza A
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Toll receptor signaling pathway
Reactome	Trafficking and processing of endosomal TLR
	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
	MyD88 dependent cascade initiated on endosome
WikiPathways	Toll-like receptor signaling pathway
	Toll-Like Receptors Cascades
	MyD88 dependent cascade initiated on endosome
	Trafficking and processing of endosomal TLR
	Regulation of toll-like receptor signaling pathway
References
Ref 523920	ClinicalTrials.gov (NCT01607372) A Study to Investigate the Safety, Pharmacodynamics and Efficacy Against Allergic Reactivity of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies. U.S. National Institutes of Health.
Ref 533262	Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement. Clin Pharmacol Ther. 2015 Oct;98(4):369-80.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.