Drug Information

Drug General Information
Drug ID
D04OBB
Former ID
DAP001063
Drug Name
Pheniramine
Synonyms
Avil; Feniramina; Feniramine; Histapyridamine; Metron; Pheniraminum; Propheniramine; Prophenpyridamine; Pyriton; Trimeton; Tripoton; Pheniramine Bimaleate; Avil (TN); Feniramina [INN-Spanish]; P-Aminosalicylsaures salz; Pheniramine (INN); Pheniramine [INN:BAN]; Pheniraminum [INN-Latin]; PHENIRAMINE (SEE ALSO PHENIRAMINE MALEATE 132-20-7); Dimethyl(3-phenyl-3-(2-pyridyl)propyl)amine; N,N-Dimethyl-3-phenyl-3-(2-pyridyl)propylamine; N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine; 1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane; 2-(3-Dimethylamino-1-phenylpropyl)pyridine; 2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine; 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-(9CI); 2-[.alpha.-(2-Dimethylaminoethyl)benzyl]pyridine; 2-[.alpha.-[2-(Dimethylamino)ethyl]benzyl]pyridine; 3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine; 3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylanine
Drug Type
Small molecular drug
Indication Hay fever [ICD9: 477; ICD10:J30] Approved [536119], [542286]
Therapeutic Class
Antiallergic Agents
Company
Aventis Pharmaceuticals Inc.
Structure
Download
2D MOL

3D MOL
Formula
C16H20N2
InChI
InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3
InChIKey
IJHNSHDBIRRJRN-UHFFFAOYSA-N
CAS Number
CAS 86-21-5
PubChem Compound ID
4761
PubChem Substance ID
100679, 615214, 4437708, 8152922, 10537059, 11335410, 11360649, 11363969, 11366531, 11369093, 11371700, 11374450, 11377255, 11461621, 11466087, 11467207, 11485010, 11485874, 11489093, 11490576, 11492781, 11494889, 15196427, 25719831, 29223845, 46505932, 47365068, 47365069, 47588879, 47662152, 47959615, 47959616, 48110340, 48184880, 48184881, 48416413, 49698877, 49855960, 50111204, 57322434, 77594960, 85787923, 90341510, 96025042, 103357869, 103928924, 104307349, 124750145, 124881161, 125677793
SuperDrug ATC ID
R06AB05
SuperDrug CAS ID
cas=000086215
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [535251]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
Ref 542286(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7267).
Ref 535251Role of central histaminergic system in lorazepam withdrawal syndrome in rats. Pharmacol Biochem Behav. 2001 Apr;68(4):777-82.

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