Drug Information

Drug General Information
Drug ID
D04NRB
Former ID
DCL000294
Drug Name
Cetilistat
Synonyms
Cametor; Cetilistat [INN]; ATL 962; ATL962; ATL-962; Cetilistat (JAN/USAN/INN); 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one
Drug Type
Small molecular drug
Indication Diabetes; Obesity [ICD9: 250, 278; ICD10:E08-E13, E66] Phase 3 [536271], [536710]
Company
Alizyme; Takeda; Norgine B.V.
Structure
Download
2D MOL

3D MOL
Formula
C25H39NO3
Canonical SMILES
CCCCCCCCCCCCCCCCOC1=NC2=C(C=C(C=C2)C)C(=O)O1
InChI
1S/C25H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-28-25-26-23-18-17-21(2)20-22(23)24(27)29-25/h17-18,20H,3-16,19H2,1-2H3
InChIKey
MVCQKIKWYUURMU-UHFFFAOYSA-N
CAS Number
CAS 282526-98-1
PubChem Compound ID
9952916
PubChem Substance ID
14928313, 24222842, 46049526, 79998193, 81044360, 92252048, 92719489, 93310783, 96025888, 121147451, 125346920, 126620765, 126651071, 126671085, 128652237, 131308796, 134338950, 135252832, 135313712, 137001360, 140274838, 152054794, 160676376, 162188868, 162258147, 164830800, 165235292, 174528660, 187072381, 196106282, 198943777, 223384844, 223666797, 223796471, 226699838, 249721013, 251893243, 251962974, 252448580, 252450870
Target and Pathway
Target(s) Gastric triacylglycerol lipase Target Info Modulator [536271]
BioCyc Pathway Triacylglycerol degradation
KEGG Pathway Glycerolipid metabolism
Metabolic pathways
Fat digestion and absorption
NetPath Pathway EGFR1 Signaling Pathway
WikiPathways Triacylglyceride Synthesis
Fatty Acid Beta Oxidation
References
Ref 536271Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond). 2007 Mar;31(3):494-9. Epub 2006 Sep 5.
Ref 536710Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
Ref 536271Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond). 2007 Mar;31(3):494-9. Epub 2006 Sep 5.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.