Drug General Information
Drug ID
D04MPB
Former ID
DIB009821
Drug Name
Bevirimat
Synonyms
DSB; Bevirimat dimeglumine; DSB 2NMG; MPC-4326; PA-457; PA-103001-01; PA-103001-04; PA-457 di-NMG; Viral maturation inhibitor (HIV), Myrexis; Viral maturation inhibitor (HIV), Myriad; Viral maturation inhibitor (HIV), Panacos; YK-FH-312; 3-O-(3' 3'-dimethylsuccinyl)-betulinic acid
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 2 [522771]
Company
Panacos
Structure
Download
2D MOL

3D MOL

Formula
C36H56O6
Canonical SMILES
[C@@]12([C@]3([C@@H]([C@@]4([C@H](C([C@@H](OC(=O)CC(C(=<br />O)O)(C)C)CC4)(C)C)CC3)C)CC[C@@H]1[C@@H]1[C@@](C(=O)O)(C<br />C2)CC[C@H]1C(=C)C)C)C
PubChem Compound ID
Target and Pathway
Target(s) HIV GAG protein Target Info Inhibitor [532230]
Reactome Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
2-LTR circle formation
Binding and entry of HIV virion
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
Integration of viral DNA into host genomic DNA
Autointegration results in viral DNA circles
APOBEC3G mediated resistance to HIV-1 infection
Vpr-mediated nuclear import of PICs
WikiPathways Host Interactions of HIV factors
HIV Life Cycle
References
Ref 522771ClinicalTrials.gov (NCT00967187) Safety and Efficacy Study of MPC-4326 for Treatment of Patients With HIV-1 Infection.. U.S. National Institutes of Health.
Ref 532230Synthesis and biological evaluation of a new derivative of bevirimat that targets the Gag CA-SP1 cleavage site. Eur J Med Chem. 2013 Apr;62:453-65.

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