Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04JMI
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| Former ID |
DIB000973
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| Drug Name |
Plasma derived human butyrylcholinesterase
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| Synonyms |
Plasma derived human butyrylcholinesterase (im, drug induced neurotoxicity); HuBChE (im, drug induced neurotoxicity), Dynport; Bioscavenger (im, drug induced neurotoxicity), Dynport/Baxter; Plasma derived human butyrylcholinesterase (im, drug induced neurotoxicity), Dynport/Baxter
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| Indication | Neurotoxicity drug-induced [ICD10:T36-T50] | Phase 1 | [1] | ||
| Company |
DynPort Vaccine Company LLC
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| Target and Pathway | |||||
| Target(s) | Cholinesterase | Target Info | Modulator | [2] | |
| PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| WikiPathways | Irinotecan Pathway | ||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00333528) A Study of Plasma-Derived Human Butyrylcholinesterase Administered Intramuscularly. U.S. National Institutes of Health. | ||||
| REF 2 | Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjug Chem. 2015 Aug 19;26(8):1753-8. | ||||
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