| Drug General Information |
| Drug ID |
D04JKL
|
| Former ID |
DIB018789
|
| Drug Name |
AIDA
|
| Synonyms |
UPF 523; UPF523; GNF-Pf-1401
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C11H11NO4
|
| InChI |
InChI=1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16)
|
| InChIKey |
LSTPKMWNRWCNLS-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
3153189, 6490748, 7980864, 8151408, 15220449, 17404682, 24277957, 26751959, 29221251, 47440469, 50070519, 50071157, 50104631, 50104632, 50491486, 53777225, 57321121, 85208945, 85230890, 90340628, 91702887, 92303493, 103098412, 103297301, 103939478, 104299517, 117545933, 118696317, 121360944, 124749464, 124879073, 124879074, 125331226, 125541072, 128536430, 131332410, 134222916, 135214308, 135649911, 135698158, 140341570, 143857956, 152043058, 162227760, 162475282, 163564073, 170481117, 176225212, 179294088, 202558549
|
| Target and Pathway |
| Target(s) |
Metabotropicglutamate receptor 1 |
Target Info |
Antagonist |
[2]
|
|---|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
FoxO signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Long-term depression
|
|
Estrogen signaling pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group I pathway
|
|
Endogenous cannabinoid signaling
|
|
Reactome
|
G alpha (q) signalling events
|
|
Class C/3 (Metabotropic glutamate/pheromone receptors)
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
GPCRs, Class C Metabotropic glutamate, pheromone
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1376). |
|---|
| REF 2 | [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. |
|---|
