Drug Information
Drug General Information | |||||
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Drug ID |
D04IMY
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Former ID |
DIB020209
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Drug Name |
leucettine L41
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [531493] | ||
Structure |
Download2D MOL |
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Formula |
C17H13N3O3
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InChI |
InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)/b13-8-
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InChIKey |
PGPHHJBZEGSUNE-JYRVWZFOSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | Target Info | Inhibitor | [531493] | |
Cdc2-like kinase 1 | Target Info | Inhibitor | [531493] | ||
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | Target Info | Inhibitor | [531493] | ||
CDC-like kinase 3 | Target Info | Inhibitor | [531493] | ||
Proto-oncogene pim-1 | Target Info | Inhibitor | [531493] | ||
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | Target Info | Inhibitor | [532050] | ||
References | |||||
Ref 531493 | Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86. | ||||
Ref 532050 | Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem. 2012 Nov 8;55(21):9312-30. |
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