Drug General Information
Drug ID
D04IMY
Former ID
DIB020209
Drug Name
leucettine L41
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531493]
Structure
Download
2D MOL

3D MOL

Formula
C17H13N3O3
InChI
InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)/b13-8-
InChIKey
PGPHHJBZEGSUNE-JYRVWZFOSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Target Info Inhibitor [531493]
Cdc2-like kinase 1 Target Info Inhibitor [531493]
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 Target Info Inhibitor [531493]
CDC-like kinase 3 Target Info Inhibitor [531493]
Proto-oncogene pim-1 Target Info Inhibitor [531493]
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 Target Info Inhibitor [532050]
KEGG Pathway Jak-STAT signaling pathway
MicroRNAs in cancer
Acute myeloid leukemia
NetPath Pathway TCR Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_20:IL9 Signaling Pathway
IL5 Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated targets of C-MYC transcriptional activation
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL5-mediated signaling events
IL3-mediated signaling events
C-MYB transcription factor network
WikiPathways mRNA ProcessingWP2858:Ectoderm Differentiation
Hematopoietic Stem Cell Differentiation
References
Ref 531493Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86.
Ref 531493Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86.
Ref 532050Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem. 2012 Nov 8;55(21):9312-30.

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