TTD | Drug: D04IHL

Drug General Information
Drug ID	D04IHL
Former ID	DNC012376
Drug Name	Tyr-Pro-D-(NMe)Phe-D-Pro-NH2
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534004]
Structure		Download 2D MOL 3D MOL
Formula	C29H37N5O5
Canonical SMILES	CN(C(CC1=CC=CC=C1)C(=O)N2CCCC2C(=O)N)C(=O)C3CCCN3C(=O)C<br />(CC4=CC=C(C=C4)O)N
InChI	1S/C29H37N5O5/c1-32(25(18-19-7-3-2-4-8-19)29(39)33-15-5-9-23(33)26(31)36)28(38)24-10-6-16-34(24)27(37)22(30)17-20-11-13-21(35)14-12-20/h2-4,7-8,11-14,22-25,35H,5-6,9-10,15-18,30H2,1H3,(H2,31,36)/t22?,23-,24?,25-/m1/s1
InChIKey	JAKBYSTWCHUQOK-RULIFZQXSA-N
PubChem Compound ID	44375783
Target and Pathway
Target(s)	Mu-type opioid receptor	Target Info	Inhibitor	[534004]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Estrogen signaling pathway
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
Pathway Interaction Database	IL4-mediated signaling events
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	TCR Signaling Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	Opioid Signalling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 534004	J Med Chem. 1993 Mar 19;36(6):708-19.A topochemical approach to explain morphiceptin bioactivity.
Ref 534004	J Med Chem. 1993 Mar 19;36(6):708-19.A topochemical approach to explain morphiceptin bioactivity.

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Drug Information