Drug Information
Drug General Information | |||||
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Drug ID |
D04IDW
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Former ID |
DIB007888
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Drug Name |
SNS-314 prodrugs
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Synonyms |
SNS-314 prodrugs (cancer); SNS-314 prodrugs (cancer), Sunesis
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Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
Company |
Sunesis Pharmaceuticals Inc
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Structure |
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Download2D MOL |
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Canonical SMILES |
O=P(O)(OCn1cc(s/c/1=N/C(=O)Nc1cc(ccc1)Cl)CCNc1ncnc2ccsc<br />12)O
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Target and Pathway | |||||
Target(s) | Aurora protein kinase | Target Info | Inhibitor | [1] | |
KEGG Pathway | Oocyte meiosis | ||||
Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
Separation of Sister Chromatids | |||||
Resolution of Sister Chromatid Cohesion | |||||
RHO GTPases Activate Formins | |||||
WikiPathways | EGF/EGFR Signaling Pathway | ||||
JAK/STAT | |||||
Gastric Cancer Network 1 | |||||
Integrated Breast Cancer Pathway | |||||
APC/C-mediated degradation of cell cycle proteins | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). | ||||
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