Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04IDW
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| Former ID |
DIB007888
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| Drug Name |
SNS-314 prodrugs
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| Synonyms |
SNS-314 prodrugs (cancer); SNS-314 prodrugs (cancer), Sunesis
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
| Company |
Sunesis Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
O=P(O)(OCn1cc(s/c/1=N/C(=O)Nc1cc(ccc1)Cl)CCNc1ncnc2ccsc<br />12)O
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| Target and Pathway | |||||
| Target(s) | Aurora protein kinase | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Oocyte meiosis | ||||
| Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
| Separation of Sister Chromatids | |||||
| Resolution of Sister Chromatid Cohesion | |||||
| RHO GTPases Activate Formins | |||||
| WikiPathways | EGF/EGFR Signaling Pathway | ||||
| JAK/STAT | |||||
| Gastric Cancer Network 1 | |||||
| Integrated Breast Cancer Pathway | |||||
| APC/C-mediated degradation of cell cycle proteins | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). | ||||
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