Drug Information

Drug General Information
Drug ID
D04GYO
Former ID
DAP001204
Drug Name
Oxiconazole
Synonyms
Oxiconazol; Oxiconazolum; Oxyconazole; Oxiconazol [INN-Spanish]; Oxiconazole (INN); Oxiconazole [INN:BAN]; Oxiconazolum [INN-Latin]; Ro 13-8996; Sgd 301-76; RO-13-8996; (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-O-(2,4-dichlorobenzyl) ethanone oxime nitrate; 1-(2,4-dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-ylethanimine; 2',4'-Dichlor-O-(2,4-dichlorbenzyl)-2-(1-imidazolyl)-(Z)-acetophenonoxim; 2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-(O-(2,4-dichlorobenzyl)oxime)
Drug Type
Small molecular drug
Indication Tinea pedis [ICD10:B35.6] Approved [538534], [551871]
Therapeutic Class
Antifungal Agents
Company
Fougera Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C18H13Cl4N3O
Canonical SMILES
C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
InChI
1S/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18+
InChIKey
QRJJEGAJXVEBNE-HKOYGPOVSA-N
CAS Number
CAS 64211-46-7
PubChem Compound ID
5353853
PubChem Substance ID
10274, 7980217, 14807454, 24591563, 39379767, 48319955, 50065009, 50122564, 50990349, 57361598, 71822671, 85787428, 92309111, 92711924, 93166843, 96025000, 103388855, 113909788, 124766357, 125312381, 126630392, 126685558, 134338444, 134609034, 135047656, 142043571, 152046181, 162175084, 172080024, 172861933, 175267699, 176484428, 179150842, 179225149, 223440376, 223555547, 223677529, 226420967, 230460673, 241114901, 252358864
SuperDrug ATC ID
D01AC11; G01AF17
SuperDrug CAS ID
cas=064211456
Target and Pathway
Target(s) Fungal Cytochrome P450 51 Target Info Inhibitor [535752], [536275]
References
Ref 538534FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019828.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535752Antifungal agents: mechanisms of action. Trends Microbiol. 2003 Jun;11(6):272-9.
Ref 536275Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9.

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