Drug General Information
Drug ID
D04FNY
Former ID
DNC009371
Drug Name
NP-506
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529888]
Structure
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2D MOL

3D MOL

Formula
C25H24N4O4
Canonical SMILES
CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=C(C=CC(=C3)C(=O)NNC4=CC=C<br />C=C4)NC2=O
InChI
1S/C25H24N4O4/c1-14-18(9-11-23(30)31)15(2)26-22(14)13-20-19-12-16(8-10-21(19)27-25(20)33)24(32)29-28-17-6-4-3-5-7-17/h3-8,10,12-13,26,28H,9,11H2,1-2H3,(H,27,33)(H,29,32)(H,30,31)/b20-13-
InChIKey
GCZQBFMPHLFNIO-MOSHPQCFSA-N
PubChem Compound ID
Target and Pathway
Target(s) Basic fibroblast growth factor receptor 1 Target Info Inhibitor [529888]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Pathways in cancer
Proteoglycans in cancer
Prostate cancer
Melanoma
Central carbon metabolism in cancer
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Angiogenesis
FGF signaling pathway
Pathway Interaction Database Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathway
WikiPathways Regulation of Actin Cytoskeleton
Endochondral Ossification
MAPK Signaling Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
Signaling Pathways in Glioblastoma
Neural Crest Differentiation
Signaling by FGFR
References
Ref 529888Bioorg Med Chem Lett. 2009 Feb 1;19(3):745-50. Epub 2008 Dec 10.5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.
Ref 529888Bioorg Med Chem Lett. 2009 Feb 1;19(3):745-50. Epub 2008 Dec 10.5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.

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