Drug Information

Drug General Information
Drug ID
D04FMB
Former ID
DIB010910
Drug Name
XK-469
Synonyms
Rac-2-[4-(7-Chloroquinoxalin-2-yloxy)phenoxy]propionic acid sodium salt
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [521500]
Structure
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2D MOL

3D MOL
Formula
C17H12ClN2NaO4
Canonical SMILES
CC(C(=O)[O-])OC1=CC=C(C=C1)OC2=CN=C3C=CC(=CC3=N2)Cl.[Na<br />+]
InChI
1S/C17H13ClN2O4.Na/c1-10(17(21)22)23-12-3-5-13(6-4-12)24-16-9-19-14-7-2-11(18)8-15(14)20-16;/h2-10H,1H3,(H,21,22);/q;+1/p-1
InChIKey
OJENKXNXJPNEPU-UHFFFAOYSA-M
CAS Number
CAS 157434-99-6
PubChem Compound ID
23675947
PubChem Substance ID
8142362, 15052687, 46225131, 50022296, 56043462, 80298263, 125747841, 135105245, 162797686, 188919884, 234344251, 242547717
Target and Pathway
Target(s) DNA topoisomerase II, beta isozyme Target Info Modulator
PANTHER Pathway DNA replication
References
Ref 521500ClinicalTrials.gov (NCT00028522) R(+)XK469 in Treating Patients With Advanced Neuroblastoma. U.S. National Institutes of Health.

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