Drug Information

Drug General Information
Drug ID
D04FHG
Former ID
DIB020638
Drug Name
PAF
Synonyms
platelet activating factor; PAF C-16
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539140]
Structure
Download
2D MOL
Formula
C26H54NO7P
InChI
InChI=1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
InChIKey
HVAUUPRFYPCOCA-AREMUKBSSA-N
PubChem Compound ID
108156
PubChem Substance ID
842037, 3153230, 7889814, 7980350, 7983809, 10234619, 16102959, 24898570, 24898858, 24899040, 26754980, 26754981, 26759314, 44437041, 46508665, 50058597, 50110858, 53787114, 77374932, 91688236, 92309864, 99300778, 99302296, 103072245, 103079553, 104046560, 104251396, 104380636, 117384587, 135065116, 135651534, 135651567, 136351135, 137272099, 142259557, 144103668, 160965465, 163687537, 164347292, 179205498, 184022000, 185973898, 226757170, 241115998, 241376180, 250136828, 252156891, 252455588, 252457424, 252468864
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Agonist [534204]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539140(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1831).
Ref 534204Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis. J Biol Chem. 1996 Sep20;271(38):23298-303.

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