Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04FBZ
|
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| Former ID |
DNC000986
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| Drug Name |
Nalorphine
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C19H21NO3
|
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| InChI |
InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1
|
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| InChIKey |
UIQMVEYFGZJHCZ-SSTWWWIQSA-N
|
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| CAS Number |
CAS 62-67-9
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
13951, 7980069, 11039367, 14752213, 39317901, 48032744, 48416307, 49992725, 50113068, 50812766, 57359132, 96024935, 103575820, 134223574, 134339919, 134340260, 134971522, 135650682, 137225348, 139813950, 160846163, 162224662, 179293397, 198970701, 198994148, 223440477, 223893849, 226424364, 241108741, 246598408
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| SuperDrug ATC ID |
V03AB02
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| SuperDrug CAS ID |
cas=000062679
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| Target and Pathway | |||||
| Target(s) | Kappa-type opioid receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Opioid prodynorphin pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1629). | ||||
| REF 2 | Apparent efficacy of kappa-opioid receptor ligands on serum prolactin levels in rhesus monkeys. Eur J Pharmacol. 1999 Nov 3;383(3):305-9. | ||||
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