Drug Information

Drug General Information
Drug ID
D04EIF
Former ID
DIB009357
Drug Name
LOXORIBINE
Synonyms
AOG; Loxoribine < Rec INN; RWJ-21757; 7-(2-Propenyl)-8-oxo-7,8-dihydroguanosine; 7-Allyl-2-amino-9-beta-D-ribofuranosylpurine-6,8(1H,9H)-dione; 7-Allyl-8-oxo-7,8-dihydroguanosine; 7A8OGua
Drug Type
Small molecular drug
Indication Immuno-stimulant [ICD10:C00-C97] Phase 2 [468129], [545189]
Structure
Download
2D MOL

3D MOL
Formula
C13H17N5O6
InChI
InChI=1S/C13H17N5O6/c1-2-3-17-6-9(15-12(14)16-10(6)22)18(13(17)23)11-8(21)7(20)5(4-19)24-11/h2,5,7-8,11,19-21H,1,3-4H2,(H3,14,15,16,22)/t5-,7-,8-,11-/m1/s1
InChIKey
VDCRFBBZFHHYGT-IOSLPCCCSA-N
CAS Number
CAS 121288-39-9
PubChem Compound ID
60737
PubChem Substance ID
15273610, 24714743, 24873084, 43118091, 47206597, 48498660, 53069090, 53789459, 57314083, 71855949, 91698223, 103245821, 104321512, 117602006, 124577274, 129457904, 135018279, 135698184, 137241208, 137747255, 144206145, 162241108, 164835211, 170466599, 178101715, 179117083, 184546893, 198979383, 224930828, 226443387, 241203263, 252156737, 252343924
Target and Pathway
Target(s) Toll-like receptor 7 Target Info Agonist [526863], [551871]
KEGG Pathway Toll-like receptor signaling pathway
Measles
Influenza A
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathway
References
Ref 468129(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5018).
Ref 545189Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002417)
Ref 526863The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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