| Drug General Information |
| Drug ID |
D03WYF
|
| Former ID |
DNC012271
|
| Drug Name |
L-695902
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Terminated |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H8ClNO4
|
| Canonical SMILES |
COC(=O)C1=C(C2=C(C=C(C=C2)Cl)NC1=O)O
|
| InChI |
1S/C11H8ClNO4/c1-17-11(16)8-9(14)6-3-2-5(12)4-7(6)13-10(8)15/h2-4H,1H3,(H2,13,14,15)
|
| InChIKey |
GEUWRNTWGHPTPU-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[2]
|
|---|
| Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[2]
|
| NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
|
Circadian entrainment
|
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Long-term potentiation
|
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Glutamatergic synapse
|
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Dopaminergic synapse
|
|
Alzheimer's disease
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Cocaine addiction
|
|
Amphetamine addiction
|
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Nicotine addiction
|
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Alcoholism
|
|
Systemic lupus erythematosushsa04014:Ras signaling pathway
|
|
Huntington's disease
|
|
PANTHER Pathway
|
Huntington disease
|
|
Ionotropic glutamate receptor pathway
|
|
Metabotropic glutamate receptor group III pathway
|
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Metabotropic glutamate receptor group I pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
Pathway Interaction Database
|
Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
|
|
Reelin signaling pathway
|
|
Reactome
|
Unblocking of NMDA receptor, glutamate binding and activation
|
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CREB phosphorylation through the activation of CaMKII
|
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Ras activation uopn Ca2+ infux through NMDA receptor
|
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
|
|
RAF/MAP kinase cascade
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
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Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
|
|
BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
|
|
Spinal Cord Injury
|
|
BDNF signaling pathway
|
|
Alzheimers Disease
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003055) |
|---|
| REF 2 | Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). |
|---|
