Drug Information

Drug General Information
Drug ID
D03URI
Former ID
DIB019975
Drug Name
GW 627368
Synonyms
saccharic acid; GW627368; GW-627368
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539251]
Structure
Download
2D MOL
Formula
C30H28N2O6S
InChI
InChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33)
InChIKey
XREWXJVMYAXCJV-UHFFFAOYSA-N
PubChem Compound ID
5312130
PubChem Substance ID
7979746, 11056895, 15134941, 39341750, 77927873, 85230004, 114157951, 124969428, 125335461, 131328965, 135650338, 163123056, 163893468, 172650084, 198941320, 204371568, 208265361, 226589234, 241377114, 244398492, 252158259, 252457941, 252819788
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Antagonist [527379]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539251(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1953).
Ref 527379Piglet saphenous vein contains multiple relaxatory prostanoid receptors: evidence for EP4, EP2, DP and IP receptor subtypes. Br J Pharmacol. 2005 Feb;144(3):405-15.

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