Drug Information

Drug General Information
Drug ID
D03TVF
Former ID
DNC003945
Drug Name
LY-293646
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526022]
Structure
Download
2D MOL

3D MOL
Formula
C17H15NO3
Canonical SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
InChI
1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
InChIKey
KKTZALUTXUZPSN-UHFFFAOYSA-N
PubChem Compound ID
9860529
Target and Pathway
Target(s) PI3K delta Target Info Inhibitor [526022]
mRNA of PI3K p110 beta Target Info Inhibitor [526022]
DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [527888]
Serine/threonine-protein kinase mTOR Target Info Inhibitor [527386]
Phosphoinositide 3 kinase Target Info Inhibitor [526022]
BioCyc Pathway Superpathway of inositol phosphate compounds
3-phosphoinositide biosynthesisPWY-6371:Superpathway of inositol phosphate compounds
3-phosphoinositide biosynthesis
KEGG Pathway Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa00562:Inositol phosphate metabolism
Choline metabolism in cancerhsa03450:Non-homologous end-joining
Cell cyclehsa04012:ErbB signaling pathway
Adipocytokine signaling pathway
MicroRNAs in cancer
Choline metabolism in cancer
NetPath Pathway FSH Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway Angiogenesis
Apoptosis signaling pathway
Axon guidance mediated by netrin
B cell activation
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Hypoxia response via HIF activation
Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Integrin signalling pathway
PDGF signaling pathway
T cell activation
VEGF signaling pathway
p53 pathway
Ras Pathway
p53 pathway feedback loops 2P00005:Angiogenesis
Interleukin signaling pathway
PI3 kinase pathway
p53 pathway feedback loops 2
CCKR signaling map STP00030:Hypoxia response via HIF activation
Pathway Interaction Database ErbB4 signaling events
TRAIL signaling pathway
Signaling events mediated by TCPTP
FAS (CD95) signaling pathway
CXCR4-mediated signaling events
EGF receptor (ErbB1) signaling pathway
Class I PI3K signaling events
ErbB1 downstream signaling
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocyte
Internalization of ErbB1
CXCR3-mediated signaling eventserbb4_pathway:ErbB4 signaling events
LPA receptor mediated events
CXCR3-mediated signaling eventsdnapk_pathway:DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling eventsil4_2pathway:IL4-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL12-mediated signaling events
CDC42 signaling events
LKB1 signaling events
Regulation of Telomerase
mTOR signaling pathway
EGFR-dependent Endothelin signaling events
IL2 signaling events mediated by PI3K
IFN-gamma pathway
CXCR3-mediated signaling events
PathWhiz Pathway Phosphatidylinositol Phosphate MetabolismPW000659:Leucine Stimulation on Insulin SignalingPW000143:Inositol Metabolism
Phosphatidylinositol Phosphate Metabolism
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-109704:PI3K Cascade
PI3K/AKT activation
Role of phospholipids in phagocytosis
Tie2 Signaling
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin interactions
VEGFA-VEGFR2 Pathway
Regulation of signaling by CBLR-HSA-5693571:Nonhomologous End-Joining (NHEJ)R-HSA-1257604:PIP3 activates AKT signaling
Macroautophagy
mTORC1-mediated signalling
HSF1-dependent transactivation
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-109704:PI3K Cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
GAB1 signalosome
PI3K events in ERBB2 signaling
Costimulation by the CD28 family
G alpha (q) signalling events
G alpha (12/13) signalling events
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
Interferon type I signaling pathways
G13 Signaling Pathway
Regulation of Actin Cytoskeleton
Insulin Signaling
IL-4 Signaling Pathway
Focal Adhesion
IL-3 Signaling Pathway
PI Metabolism
Signaling by the B Cell Receptor (BCR)
Interleukin-2 signaling
PIP3 activates AKT signaling
Nanoparticle-mediated activation of receptor signaling
Signaling Pathways in Glioblastoma
Interleukin-3, 5 and GM-CSF signaling
MicroRNAs in cardiomyocyte hypertrophy
Regulation of toll-like receptor signaling pathway
AMPK SignalingWP75:Toll-like receptor signaling pathway
Fc epsilon receptor (FCERI) signaling
Fcgamma receptor (FCGR) dependent phagocytosis
DAP12 interactions
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
TCR signaling
Signaling by PDGF
Signaling by Insulin receptor
NGF signalling via TRKA from the plasma membrane
Nephrin interactions
GPVI-mediated activation cascade
Cell surface interactions at the vascular wall
AMPK SignalingWP707:DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage ResponseWP673:ErbB Signaling Pathway
Senescence and Autophagy in Cancer
EGF/EGFR Signaling Pathway
Wnt Signaling Pathway Netpath
Extracellular vesicle-mediated signaling in recipient cells
Cardiac Hypertrophic Response
Polycystic Kidney Disease Pathway
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
Oncostatin M Signaling Pathway
TSLP Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
TSH signaling pathway
RANKL/RANK Signaling Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Costimulation by the CD28 family
Type II diabetes mellitus
TOR Signaling
Serotonin HTR1 Group and FOS Pathway
Copper homeostasis
Signaling of Hepatocyte Growth Factor Receptor
Transcriptional activation by NRF2
IL1 and megakaryotyces in obesity
Signaling by ERBB4
Signaling by ERBB2
Signaling by SCF-KIT
Gastrin-CREB signalling pathway via PKC and MAPK
Integrated Pancreatic Cancer Pathway
Regulation of Microtubule Cytoskeleton
Signaling by FGFR
Signaling by EGFR
GPCR downstream signaling
Angiogenesis
AMPK Signaling
References
Ref 526022Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13.LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.
Ref 526022Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13.LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

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