Drug General Information
Drug ID
D03TNA
Former ID
DIB016779
Drug Name
ABT-724
Synonyms
2-[4-(2-Pyridyl)piperazin-1-ylmethyl]-1H-benzimidazole maleate
Drug Type
Small molecular drug
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Discontinued in Phase 2 [547821]
Structure
Download
2D MOL

3D MOL

Formula
C17H19N5
Canonical SMILES
C(N1CCN(CC1)c2ccccn2)c3nc4ccccc4[nH]3
InChI
1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)
InChIKey
FRPJGTNLZNXQEX-UHFFFAOYSA-N
CAS Number
CAS 474417-17-9
PubChem Compound ID
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Agonist [544413]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 547821Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019657)
Ref 544413Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6758-6763.

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