Drug General Information
Drug ID	D03TMD
Former ID	DNC003503
Drug Name	Barbituric acid derivative
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551407]
Structure		Download 2D MOL 3D MOL
Formula	C16H11F3N2O3S
PubChem Compound ID	3003157
Target and Pathway
Target(s)	Neuronal acetylcholine receptor protein, alpha-7 chain	Target Info	Antagonist	[551407]
	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[551407]
	Gamma-aminobutyric-acid receptor alpha-5 subunit	Target Info	Inhibitor	[551407]
	Gamma-aminobutyric-acid receptor alpha-3 subunit	Target Info	Inhibitor	[551407]
	Neuronal acetylcholine receptor protein, alpha-4 chain	Target Info	Antagonist	[551407]
	Gamma-aminobutyric-acid receptor alpha-2 subunit	Target Info	Inhibitor	[551407]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Nicotine addiction
	Chemical carcinogenesishsa04080:Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Nicotinic acetylcholine receptor signaling pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
	Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP706:SIDS Susceptibility Pathways
	Nicotine Activity on Dopaminergic NeuronsWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 551407	Whiting PJ: The <span class="caps">GABAA</span> receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57.
Ref 551407	Whiting PJ: The <span class="caps">GABAA</span> receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57.

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