Drug General Information
Drug ID
D03RNX
Former ID
DIB001692
Drug Name
EPC-K1
Synonyms
CHX-3107; Phosphoric acid 2-L-ascorbyl D,L-alpha-tocopheryl diester potassium salt; 2-O-[Hydroxy[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yloxy]phosphoryl]-L-ascorbic acid potassium salt
Drug Type
Small molecular drug
Indication Nerve injury [ICD10:T14.4] Discontinued in Phase 2 [546374]
Structure
Download
2D MOL

3D MOL

Formula
C35H57KO10P+
Canonical SMILES
CC1=C2C(=C(C(=C1C)OP(=O)(O)OC3=C(C(OC3=O)C(CO)O)O)C)CCC<br />(O2)(C)CCCC(C)CCCC(C)CCCC(C)C.[K+]
InChI
1S/C35H57O10P.K/c1-21(2)12-9-13-22(3)14-10-15-23(4)16-11-18-35(8)19-17-27-26(7)30(24(5)25(6)31(27)43-35)44-46(40,41)45-33-29(38)32(28(37)20-36)42-34(33)39;/h21-23,28,32,36-38H,9-20H2,1-8H3,(H,40,41);/q;+1/t22-,23-,28+,32-,35-;/m1./s1
InChIKey
VIHIKSJKXIMMLV-FZTHFCCHSA-N
CAS Number
CAS 127061-56-7
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Phospholipase A2 Target Info Inhibitor [533699], [551871]
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorption
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways Glycerophospholipid biosynthesis
References
Ref 546374Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007770)
Ref 533699Posttreatment with EPC-K1, an inhibitor of lipid peroxidation and of phospholipase A2 activity, reduces functional deficits after global ischemia in rats. Brain Res Bull. 1995;36(3):257-60.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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