| Drug General Information |
| Drug ID |
D03QHG
|
| Former ID |
DNC007009
|
| Drug Name |
8-(2,2-dimethylpropyl)naringenin
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H22O5
|
| Canonical SMILES |
CC(C)(C)CC1=C(C=C(C2=C1OC(CC2=O)C3=CC=C(C=C3)O)O)O
|
| InChI |
1S/C20H22O5/c1-20(2,3)10-13-14(22)8-15(23)18-16(24)9-17(25-19(13)18)11-4-6-12(21)7-5-11/h4-8,17,21-23H,9-10H2,1-3H3/t17-/m0/s1
|
| InChIKey |
SBFJMGDUIWYKMQ-KRWDZBQOSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Estrogen receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Estrogen receptor beta |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Estrogen signaling pathway
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|
Prolactin signaling pathway
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|
Thyroid hormone signaling pathway
|
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Endocrine and other factor-regulated calcium reabsorption
|
|
Proteoglycans in cancerhsa04915:Estrogen signaling pathway
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NetPath Pathway
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FSH Signaling Pathway
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EGFR1 Signaling Pathway
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RANKL Signaling Pathway
|
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by HDAC Class II
|
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Plasma membrane estrogen receptor signaling
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LKB1 signaling events
|
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Regulation of Telomerase
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ATF-2 transcription factor network
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AP-1 transcription factor network
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FOXM1 transcription factor network
|
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Validated nuclear estrogen receptor alpha network
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Signaling mediated by p38-alpha and p38-beta
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FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
|
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Validated nuclear estrogen receptor beta network
|
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Reactome
|
Nuclear signaling by ERBB4
|
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Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
|
|
WikiPathways
|
Estrogen signaling pathway
|
|
Nuclear Receptors Meta-Pathway
|
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Estrogen Receptor Pathway
|
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Signaling by ERBB4
|
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JAK/STAT
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Integrated Pancreatic Cancer Pathway
|
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Leptin signaling pathway
|
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miR-targeted genes in muscle cell - TarBase
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Integrated Breast Cancer Pathway
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Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
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Ovarian Infertility Genes
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|
Nuclear Receptors
|
| References |
| REF 1 | J Med Chem. 2006 Dec 14;49(25):7357-65.Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors alphaand beta. |
|---|
