Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03PKL
|
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| Former ID |
DNCL003569
|
||||
| Drug Name |
GSK933776
|
||||
| Synonyms |
GSK-933776
|
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| Indication | Geographic retinal atrophy; Macular degeneration [ICD9: 362.5; ICD10:H35.3] | Phase 2 | [1] | ||
| Company |
GlaxoSmithKline
|
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| Target and Pathway | |||||
| Target(s) | Amyloid beta A4 protein | Target Info | Modulator | [2] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Degradation of the extracellular matrix | |||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| WikiPathways | Notch Signaling Pathway | ||||
| Signaling by ERBB4 | |||||
| Signaling by NOTCH3 | |||||
| Signaling by NOTCH4 | |||||
| Signaling by NOTCH1 | |||||
| Signaling by NOTCH2 | |||||
| Notch Signaling Pathway | |||||
| Alzheimers Disease | |||||
| Signalling by NGF | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01342926) Clinical Study to Investigate Safety and Efficacy of GSK933776 in Adult Patients With Geographic Atrophy Secondary to Age-related Macular Degeneration. U.S. National Institutes of Health. | ||||
| REF 2 | Bapineuzumab. Expert Opin Biol Ther. 2010 July; 10(7): 1121-1130. | ||||
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