Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03IVG
|
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| Former ID |
DIB020045
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| Drug Name |
imiloxan
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| Synonyms |
RS-21361; GNF-Pf-2156
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H16N2O2
|
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| InChI |
InChI=1S/C14H16N2O2/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11/h3-8,11H,2,9-10H2,1H3
|
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| InChIKey |
UXABARREKCJULM-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7734666, 7979597, 10243413, 12012640, 15019917, 26752007, 29311505, 47500596, 47647598, 48244473, 50104679, 57344592, 79391242, 85209112, 85788122, 90341379, 103073023, 103084716, 103411089, 104171179, 104380223, 117603563, 124749929, 124880475, 124880476, 126437710, 129432694, 131332122, 135089115, 136351334, 136368380, 137006275, 143259520, 144203726, 170466588, 178100464, 179293618, 184591510, 223682208, 224859049, 227042536, 249980832
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| Target and Pathway | |||||
| Target(s) | Alpha-2B adrenergic receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3470). | ||||
| REF 2 | Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4. | ||||
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