Drug Information

Drug General Information
Drug ID
D03HQK
Former ID
DNC005639
Drug Name
2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527458]
Structure
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2D MOL

3D MOL
Formula
C16H11N3O
Canonical SMILES
C1=CC=C(C=C1)C2=CN=C(O2)NC3=CC=CC=C3C#N
InChI
1S/C16H11N3O/c17-10-13-8-4-5-9-14(13)19-16-18-11-15(20-16)12-6-2-1-3-7-12/h1-9,11H,(H,18,19)
InChIKey
FPMCYJLZCOBPEC-UHFFFAOYSA-N
PubChem Compound ID
5329843
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 3 Target Info Inhibitor [527458]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [527458]
mRNA of VEGFR1 Target Info Inhibitor [527458]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesionhsa04014:Ras signaling pathway
Endocytosis
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endotheliumhif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGFR1 specific signals
Reactome VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
WikiPathways Signaling by VEGFWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
Angiogenesis
References
Ref 527458J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
Ref 527458J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.

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