| Drug General Information |
| Drug ID |
D03HQK
|
| Former ID |
DNC005639
|
| Drug Name |
2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H11N3O
|
| Canonical SMILES |
C1=CC=C(C=C1)C2=CN=C(O2)NC3=CC=CC=C3C#N
|
| InChI |
1S/C16H11N3O/c17-10-13-8-4-5-9-14(13)19-16-18-11-15(20-16)12-6-2-1-3-7-12/h1-9,11H,(H,18,19)
|
| InChIKey |
FPMCYJLZCOBPEC-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Vascular endothelial growth factor receptor 3 |
Target Info |
Inhibitor |
[1]
|
|---|
| Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[1]
|
| mRNA of VEGFR1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
PI3K-Akt signaling pathway
|
|
Focal adhesionhsa04014:Ras signaling pathway
|
|
Endocytosis
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
|
Proteoglycans in cancerhsa04014:Ras signaling pathway
|
|
HIF-1 signaling pathway
|
|
Transcriptional misregulation in cancer
|
|
Rheumatoid arthritis
|
|
NetPath Pathway
|
TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
VEGF signaling pathway
|
|
Pathway Interaction Database
|
VEGF and VEGFR signaling network
|
|
VEGFR3 signaling in lymphatic endotheliumhif2pathway:HIF-2-alpha transcription factor network
|
|
Beta3 integrin cell surface interactions
|
|
Signaling events mediated by TCPTP
|
|
SHP2 signaling
|
|
S1P1 pathway
|
|
Integrins in angiogenesis
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
|
|
HIF-2-alpha transcription factor network
|
|
S1P3 pathway
|
|
VEGFR1 specific signals
|
|
Reactome
|
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
|
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
WikiPathways
|
Signaling by VEGFWP306:Focal Adhesion
|
|
Nifedipine Activity
|
|
Cardiac Progenitor Differentiation
|
|
Signaling by VEGF
|
|
AngiogenesisWP306:Focal Adhesion
|
|
Angiogenesis
|
| References |
| REF 1 | J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. |
|---|
