Drug General Information |
Drug ID |
D03HQK
|
Former ID |
DNC005639
|
Drug Name |
2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C16H11N3O
|
Canonical SMILES |
C1=CC=C(C=C1)C2=CN=C(O2)NC3=CC=CC=C3C#N
|
InChI |
1S/C16H11N3O/c17-10-13-8-4-5-9-14(13)19-16-18-11-15(20-16)12-6-2-1-3-7-12/h1-9,11H,(H,18,19)
|
InChIKey |
FPMCYJLZCOBPEC-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Vascular endothelial growth factor receptor 3 |
Target Info |
Inhibitor |
[1]
|
Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[1]
|
mRNA of VEGFR1 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
Cytokine-cytokine receptor interaction
|
PI3K-Akt signaling pathway
|
Focal adhesionhsa04014:Ras signaling pathway
|
Endocytosis
|
VEGF signaling pathway
|
Focal adhesion
|
Proteoglycans in cancerhsa04014:Ras signaling pathway
|
HIF-1 signaling pathway
|
Transcriptional misregulation in cancer
|
Rheumatoid arthritis
|
NetPath Pathway
|
TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
PANTHER Pathway
|
Angiogenesis
|
VEGF signaling pathway
|
Pathway Interaction Database
|
VEGF and VEGFR signaling network
|
VEGFR3 signaling in lymphatic endotheliumhif2pathway:HIF-2-alpha transcription factor network
|
Beta3 integrin cell surface interactions
|
Signaling events mediated by TCPTP
|
SHP2 signaling
|
S1P1 pathway
|
Integrins in angiogenesis
|
Signaling events mediated by VEGFR1 and VEGFR2
|
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
|
HIF-2-alpha transcription factor network
|
S1P3 pathway
|
VEGFR1 specific signals
|
Reactome
|
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
VEGF binds to VEGFR leading to receptor dimerization
|
Integrin cell surface interactions
|
EPHA-mediated growth cone collapse
|
VEGFA-VEGFR2 Pathway
|
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
WikiPathways
|
Signaling by VEGFWP306:Focal Adhesion
|
Nifedipine Activity
|
Cardiac Progenitor Differentiation
|
Signaling by VEGF
|
AngiogenesisWP306:Focal Adhesion
|
Angiogenesis
|
References |
REF 1 | J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. |