Drug Information
Drug General Information | |||||
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Drug ID |
D03ESO
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Former ID |
DPR000055
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Drug Name |
GW-3333
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Synonyms |
GW3333; Gw 3333; N2-[(2r,3s)-3-[formyl(hydroxy)amino]-4-methyl-2-(2-methylpropyl)pentanoyl]-n-pyridin-2-yl-l-isoleucinamide; (2R,3S)-3-(Formyl-hydroxyamino)-2-(2-methyl-1-propyl)-4-methylpentanoic acid, ((1S,2S)-2-methyl-1-(2-pyridylcarbamoyl)-1-butyl)amide; (2R,3S)-3-[formyl(hydroxy)amino]-4-methyl-N-[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide
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Drug Type |
Small molecular drug
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Indication | Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] | Preclinical | [536223] | ||
Company |
GlaxoSmithKline
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Structure |
Download2D MOL |
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Formula |
C22H36N4O4
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Canonical SMILES |
CCC(C)C(C(=O)NC1=CC=CC=N1)NC(=O)C(CC(C)C)C(C(C)C)N(C=O)<br />O
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InChI |
1S/C22H36N4O4/c1-7-16(6)19(22(29)24-18-10-8-9-11-23-18)25-21(28)17(12-14(2)3)20(15(4)5)26(30)13-27/h8-11,13-17,19-20,30H,7,12H2,1-6H3,(H,25,28)(H,23,24,29)/t16-,17+,19-,20-/m0/s1
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InChIKey |
SMZPWUUYPYYHIV-HNJRGHQBSA-N
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CAS Number |
CAS 212609-68-2
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | ADAM 17 | Target Info | Inhibitor | [536223] | |
Pathway Interaction Database | ErbB4 signaling events | ||||
TNF receptor signaling pathway | |||||
p75(NTR)-mediated signaling | |||||
Reactome | Nuclear signaling by ERBB4 | ||||
Collagen degradation | |||||
Regulated proteolysis of p75NTR | |||||
Activated NOTCH1 Transmits Signal to the Nucleus | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 t(7 | |||||
M1580_K2555) Translocation Mutant | |||||
Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
TNF signaling | |||||
Growth hormone receptor signaling | |||||
References |
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